Article
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers.
Brain imaging and behavior - 1 Mar 2013
Patel Krishna T, Stevens Michael C, Pearlson Godfrey D, Winkler Anderson M, Hawkins Keith A, Skudlarski Pawel, Bauer Lance O
Abstract excerpt
Alzheimer's disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers...
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