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Article

Opposite Neural Trajectories of Apolipoprotein E ϵ4 and ϵ2 Alleles with Aging Associated with Different Risks of Alzheimer's Disease.

Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2016

Shu Hao, Shi Yongmei, Chen Gang, Wang Zan, Liu Duan, Yue Chunxian, Ward B Douglas, Li Wenjun, Xu Zhan, Chen Guangyu, Guo Qihao, Xu Jun, Li Shi-Jiang, Zhang Zhijun

Abstract excerpt

The apolipoprotein E (APOE) ϵ4 allele is a confirmed genetic risk factor and the APOE ϵ2 allele is a protective factor related to late-onset Alzheimer's disease (AD). Intriguingly, recent studies demonstrated similar brain function alterations between APOE ϵ2 and ϵ4 alleles, despite their opposite susceptibilities to AD. To address this apparent discrepancy, we recruited 129 cognitively normal elderly subjects,...

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Identifiers

PMID: 25336599
DOI: 10.1093/cercor/bhu237
PMCID: PMC4785940

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APOE

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