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Article

Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4.

Brain imaging and behavior - 1 Jun 2017

Su Yun Yan, Zhang Xiao Dong, Schoepf U Joseph, Varga-Szemes Akos, Stubenrauch Andrew, Liang Xue, Zheng Li Juan, Zheng Gang, Kong Xiang, Xu Qiang, Wang Shou Ju, Qi Rong Feng, Lu Guang Ming, Zhang Long Jiang

Abstract excerpt

In this study, we used resting-state functional magnetic resonance imaging to explore the genetic effects of amyloid precursor protein (APP) or presenilins mutation and apolipoprotein E (APOE) ε4 on the default-mode network (DMN) in cognitively intact young adults (24.1 ± 2.5 years). Both the APP or presenilin-1/2 group and the APOE ε4 group had significantly lower DMN functional connectivity (FC) in the some...

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Source

Identifiers

PMID: 27189159
DOI: 10.1007/s11682-016-9556-z

Genes

APOE
APP
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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