Article
The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets.
PloS one - 1 Jan 2016
Rasheed Humaira, McKinney Cushla, Stamp Lisa K, Dalbeth Nicola, Topless Ruth K, Day Richard, Kannangara Diluk, Williams Kenneth, Smith Malcolm, Janssen Matthijs, Jansen Tim L, Joosten Leo A, Radstake Timothy R, Riches Philip L, Tausche Anne-Kathrin, Lioté Frederic, Lu Leo, Stahl Eli A, Choi Hyon K, So Alexander, Merriman Tony R
Abstract excerpt
Deposition of crystallized monosodium urate (MSU) in joints as a result of hyperuricemia is a central risk factor for gout. However other factors must exist that control the progression from hyperuricaemia to gout. A previous genetic association study has implicated the toll-like receptor 4 (TLR4) which activates the NLRP3 inflammasome via the nuclear factor-κB signaling pathway upon stimulation by MSU crystals....
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