Article

Gout Risk Allele Regulating <em>IRF5</em> Expression is Associated with Enhanced IL-1β Production in Response to Palmitate and Monosodium Urate Crystals

2025-09-26

Abstract excerpt

<h4>Background: </h4> Interferon Regulatory Factor 5 plays an important role in the regulation of innate immune responses by amplifying the Nuclear Factor κB response, which is critical in gout inflammation. Furthermore, the rs4728141 polymorphism C allele was associated with both increased IRF5 expression and susceptibility to gout. We examine the association between rs4728141 and cytokine production in response...

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Literature Corpus work: 7625768e-ce76-5a82-b0d0-deab85f7fd06
DOI: 10.20944/preprints202509.2154.v1

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