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Article

The genetics of gout: translation into clinical practice

1 Aug 2025

Abstract excerpt

Gout results from an innate immune response to monosodium urate crystals deposited in joints in people with hyperuricemia. Central to this is activation of the NLRP3 inflammasome and secretion of interleukin-1β. The pathogenic mechanism of NLRP3 inflammasome activation in gout is not well understood. However, recent genome-wide association studies (GWAS) in gout have revealed new pathogenic pathways, for example,...

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Share to Eosinophilic Disorders and Syndromes
Share to Gout, Hyperuricemia, Uric Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40874164
DOI: 10.1177/1759720x251366360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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