Article
Association of TLR4 Gene rs2149356 polymorphism with primary gouty arthritis in a case-control study.
PloS one - 1 Jan 2013
Qing Yu-Feng, Zhou Jing-Guo, Zhang Quan-Bo, Wang Dong-Sheng, Li Min, Yang Qi-Bin, Huang Cui-Ping, Yin Ling, Pan Shu-Yue, Xie Wen-Guang, Zhang Meng-Yun, Pu Meng-Jun, Zeng Mei
Abstract excerpt
BACKGROUND: The toll-like receptor (TLR)4-interleukin1β (IL1β) signaling pathway is involved in the monosodium urate (MSU)-mediated inflammation. The aim of this present study was to determine whether the TLR4 gene rs2149356 SNP is associated with gouty arthritis (GA) susceptibility and whether rs2149356 SNP impacts the TLR4-IL1β signaling pathway molecules expression. METHODS AND FINDINGS: The rs2149356 SNP was...
Read the complete abstract on PubMed