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Article

Toll-Like receptor 4 (TLR4) polymorphism rs2149356 and risk of gout in a Spanish cohort.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2020

Torres Rosa J

Abstract excerpt

Gout is the most common arthritis and it is associated to urate monosodium crystals deposits in articulations, kidney and soft tissue. The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1β. Toll-like receptor 4 (TLR4) is involved in this response. Although serum urate level is a strong predictor of incident gout, only about...

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PMID: 32552358
DOI: 10.1080/15257770.2020.1780438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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