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Article

Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis.

Rheumatology (Oxford, England) - 1 Mar 2017

Chang Wan-Chun, Jan Wu Yeong-Jian, Chung Wen-Hung, Lee Yun-Shien, Chin See-Wen, Chen Ting-Jui, Chang Yu-Sun, Chen Der-Yuan, Hung Shuen-Iu

Abstract excerpt

Objective: Gout is characterized by recurrent attacks of arthritis with hyperuricaemia and urate crystal-induced inflammation. Although urate transporters are known as risk factors, the immunogenetics of gouty inflammation remains unclear. This study aimed to investigate the genetic association between immune/metabolism regulators and gout. Methods: We enrolled 448 gout patients and 943 population controls from...

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Share to Caspase 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1beta

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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Source

Identifiers

PMID: 28394398
DOI: 10.1093/rheumatology/kew337

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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