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Article

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.

Nature reviews. Rheumatology - 1 Aug 2024

Leask Megan P, Crișan Tania O, Ji Aichang, Matsuo Hirotaka, Köttgen Anna, Merriman Tony R

Abstract excerpt

The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in articular structures and culminating in an innate immune response, mediated by the NLRP3 inflammasome, to the deposited crystals. Large genome-wide association studies (GWAS) of serum urate levels initially identified the genetic variants with the strongest effects, mapping...

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Identifiers

PMID: 38992217
DOI: 10.1038/s41584-024-01137-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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