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Article

An update on the genetics of hyperuricaemia and gout.

Nature reviews. Rheumatology - 1 Jun 2018

Major Tanya J, Dalbeth Nicola, Stahl Eli A, Merriman Tony R

Abstract excerpt

A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to the formation of monosodium urate crystals. The clinical features of gout result from an individual's immune response to these deposited crystals. Genome-wide association studies (GWAS) have confirmed the importance of urate excretion in the control of serum urate levels and the risk of gout and have identified the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29740155
DOI: 10.1038/s41584-018-0004-x

Genes

NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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