Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

Nature immunology - 1 Jul 2010

Ouyang Weiming, Beckett Omar, Ma Qian, Paik Ji-hye, DePinho Ronald A, Li Ming O

Abstract excerpt

CD4(+) regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice with T cell-specific deletion of both the Foxo1 and Foxo3 transcription factors (collectively called 'Foxo proteins' here) developed a fatal multifocal inflammatory disorder due in part to T(reg) cell defects. Foxo proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4 Antigens
Share to Forkhead Box Protein O1
Share to Forkhead Box Protein O3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Regulatory Elements, Transcriptional

Share to T-Lymphocytes, Regulatory

Share to Thymus Gland

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 20467422
DOI: 10.1038/ni.1884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.PMID 20467422Read ↗

Transcriptional control of regulatory T-cell differentiation.Semantic proximity Read ↗

Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.Semantic proximity Read ↗

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.Semantic proximity Read ↗

Foxp3 enhancers synergize to maximize regulatory T cell suppressive capacitySemantic proximity Read ↗

Foxp3: a genetic foundation for regulatory T cell differentiation and function.Semantic proximity Read ↗

Regulatory T cells and Foxp3.Semantic proximity Read ↗

Forkhead box P3: the peacekeeper of the immune system.Semantic proximity Read ↗

Transcriptional regulation of <i>Foxp3</i> gene: Multiple signal pathways on the roadSemantic proximity Read ↗

Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells.Semantic proximity Read ↗

Foxp3 occupancy and regulation of key target genes during T-cell stimulation.Semantic proximity Read ↗

FOXP3 modifies the phenotypic and functional properties of regulatory T cells.Semantic proximity Read ↗

FOXP3: of mice and men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.