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Article

AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signaling.

European journal of immunology - 1 Feb 2014

Liu Yun, Xu Yingqian, Sun Jiabin, Ma Aihui, Zhang Feng, Xia Suhua, Xu Guiqin, Liu Yongzhong

Abstract excerpt

The generation of CD4⁺Foxp3⁺ Treg cells in the thymus is crucial for immune homeostasis and self-tolerance. Recent studies have shown Treg-cell plasticity when Th-related transcriptional factors and cytokines are present. However, the mechanisms that maintain the stability of Treg cells are poorl...

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Source

Identifiers

PMID: 24165986
DOI: 10.1002/eji.201243291

Genes

TNF
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24165986-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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