Article
Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling.
Cellular signalling - 1 May 2011
Doubravska Lenka, Krausova Michaela, Gradl Dietmar, Vojtechova Martina, Tumova Lucie, Lukas Jan, Valenta Tomas, Pospichalova Vendula, Fafilek Bohumil, Plachy Jiri, Sebesta Ondrej, Korinek Vladimir
Abstract excerpt
The Wnt family of proteins is a group of extracellular signalling molecules that regulate cell-fate decisions in developing and adult tissues. It is presumed that all 19 mammalian Wnt family members contain two types of post-translational modification: the covalent attachment of fatty acids at two distinct positions, and the N-glycosylation of multiple asparagines. We examined how these modifications contribute...
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