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Article

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

Nature - 1 Sept 2020

McGough Ian J, Vecchia Luca, Bishop Benjamin, Malinauskas Tomas, Beckett Karen, Joshi Dhira, O'Reilly Nicola, Siebold Christian, Jones E Yvonne, Vincent Jean-Paul

Abstract excerpt

A relatively small number of proteins have been suggested to act as morphogens-signalling molecules that spread within tissues to organize tissue repair and the specification of cell fate during development. Among them are Wnt proteins, which carry a palmitoleate moiety that is essential for signalling activity1-3. How a hydrophobic lipoprotein can spread in the aqueous extracellular space is unknown. Several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32699409
DOI: 10.1038/s41586-020-2498-z
PMCID: PMC7610841

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