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Article

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.

Biology of reproduction - 1 Nov 2017

Farah Omar, Biechele Steffen, Rossant Janet, Dufort Daniel

Abstract excerpt

The secretion of mammalian Wnt ligands within the cell is dependent on the activity of Porcupine, a gene located on the X-chromosome that encodes for a membrane-bound O-acyl transferase. Here, we report that postnatal ablation of Porcupine in the uterine luminal epithelium alone results in the decrease in endometrial gland number. Despite having uterine glands, mutant females are completely infertile. Epithelial...

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Identifiers

PMID: 29036275
DOI: 10.1093/biolre/iox119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.PMID 29036275Read ↗

Porcn-dependent Wnt signaling is not required prior to mouse gastrulationSemantic proximity Read ↗

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Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.Semantic proximity Read ↗

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Fatty acylation of Wnt proteins.Semantic proximity Read ↗

Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibitionSemantic proximity Read ↗

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.Semantic proximity Read ↗

Illuminating the “Black Box” of Progesterone-Dependent Embryo Implantation Using Engineered MiceSemantic proximity Read ↗

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