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Article

Loss of Porcupine impairs convergent extension during gastrulation in zebrafish.

Journal of cell science - 1 May 2012

Chen Qiuhong, Takada Ritsuko, Takada Shinji

Abstract excerpt

Porcupine (Porcn), an O-acyltransferase located in the endoplasmic reticulum (ER), is required for lipidation of Wnt proteins to enable their trafficking from the ER in mammalian cell culture. However, it is unclear whether Porcn is required for trafficking of all members of the Wnt family. In this study, we investigated the function of Porcn in zebrafish embryos. We identified two zebrafish homologs of...

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Identifiers

PMID: 22357957
DOI: 10.1242/jcs.098368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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