Article
Different Somatic Mutations in Multinodular Adrenals With Aldosterone-Producing Adenoma.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2015
Fernandes-Rosa Fabio Luiz, Giscos-Douriez Isabelle, Amar Laurence, Gomez-Sanchez Celso E, Meatchi Tchao, Boulkroun Sheerazed, Zennaro Maria-Christina
Abstract excerpt
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D are found in aldosterone-producing adenoma. In addition, adrenals with aldosterone-producing adenomas show cortical remodeling and frequently multiple secondary nodules. Our aim was to investigate whether different aldosterone-producing nodules from the same adrenal share the same...
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