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Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals

12 May 2017

Abstract excerpt

CONTEXT: Aldosterone synthase (CYP11B2) immunohistochemistry and next-generation sequencing (NGS) have revealed the frequent presence of aldosterone-producing cell clusters (APCCs) harboring somatic mutations in aldosterone-regulating genes in adrenals from Americans without defined hypertension status. OBJECTIVE: Determine the frequency and somatic mutation status of APCCs in a Japanese nonhypertensive cohort....

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PMID: 29264530
DOI: 10.1210/js.2017-00134

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