Article
Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015
Nishimoto Koshiro, Tomlins Scott A, Kuick Rork, Cani Andi K, Giordano Thomas J, Hovelson Daniel H, Liu Chia-Jen, Sanjanwala Aalok R, Edwards Michael A, Gomez-Sanchez Celso E, Nanba Kazutaka, Rainey William E
Abstract excerpt
Primary aldosteronism (PA) represents the most common cause of secondary hypertension, but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell clusters (APCCs) with high expression of aldosterone synthase (CYP11B2) were found in both normal and PA adrenal tissue. PA-causing aldosterone-producing adenomas (APAs) harbor mutations in genes encoding ion channels/pumps that...
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