Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2023

Gong Siyuan, Sun Na, Meyer Lucie S, Tetti Martina, Koupourtidou Christina, Krebs Stefan, Masserdotti Giacomo, Blum Helmut, Rainey William E, Reincke Martin, Walch Axel, Williams Tracy Ann

Abstract excerpt

BACKGROUND: Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone overproduction. APAs with a mutation in KCNJ5 (APA-KCNJ5MUT) are characterized by heterogeneous CYP11B2 (aldosterone synthase) expression, a particular cellular composition and larger tumor diameter than those with wild-type KCNJ5 (APA-KCNJ5WT). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Adrenal Cortex Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Adrenocortical Adenoma

Share to Aldosterone

Share to Cytochrome P-450 CYP11B2

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Hyperaldosteronism

Share to Multiomics

Source

Open in PubMed Open full text

Identifiers

PMID: 37125608
DOI: 10.1161/HYPERTENSIONAHA.123.20921
PMCID: PMC10330203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas.PMID 37125608Read ↗

Adrenocortical cell and macrophage heterogeneity at single-cell spatial resolution in KCNJ5-mutant aldosterone-producing adenomas.Semantic proximity Read ↗

Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.Semantic proximity Read ↗

Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone-producing adenomas with KCNJ5 mutationsSemantic proximity Read ↗

Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.Semantic proximity Read ↗

Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations.Semantic proximity Read ↗

Molecular Heterogeneity in Aldosterone-Producing Adenomas.Semantic proximity Read ↗

Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism.Semantic proximity Read ↗

Histopathology and Molecular Profiling of Primary Aldosteronism.Semantic proximity Read ↗

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.Semantic proximity Read ↗

Molecular characteristics of the KCNJ5 mutated aldosterone-producing adenomas.Semantic proximity Read ↗

Genetic and Histopathologic Intertumor Heterogeneity in Primary AldosteronismSemantic proximity Read ↗

Histopathology and Genetic Causes of Primary Aldosteronism in Young Adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.