Article
TET2 Mutation in Adult T-Cell Leukemia/Lymphoma.
Journal of clinical and experimental hematopathology : JCEH - 1 Jan 2015
Shimoda Kazuya, Shide Kotaro, Kameda Takuro, Hidaka Tomonori, Kubuki Yoko, Kamiunten Ayako, Sekine Masaaki, Akizuki Keiichi, Shimoda Haruko, Yamaji Takumi, Nakamura Kenichi, Abe Hiroo, Miike Tadashi, Iwakiri Hisayoshi, Tahara Yoshihiro, Sueta Mitsue, Yamamoto Shojiro, Hasuike Satoru, Nagata Kenji, Kitanaka Akira
Abstract excerpt
Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7～12% of diffuse large B-cell lymphomas and 18～83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated...
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