Article
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.
Blood - 16 Aug 2012
Lemonnier François, Couronné Lucile, Parrens Marie, Jaïs Jean-Philippe, Travert Marion, Lamant Laurence, Tournillac Olivier, Rousset Therese, Fabiani Bettina, Cairns Rob A, Mak Tak, Bastard Christian, Bernard Olivier A, de Leval Laurence, Gaulard Philippe
Abstract excerpt
Inactivating mutations of the Ten-Eleven Translocation 2 (TET2) gene were first identified in myeloid malignancies and more recently in peripheral T-cell lymphomas (PTCLs). In the present study, we investigated the presence of TET2 coding sequence mutations and their clinical relevance in a large cohort of 190 PTCL patients. TET2 mutations were identified in 40 of 86 (47%) cases of angioimmunoblastic T-cell...
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