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Article

Landscape of TET2 Mutations: From Hematological Malignancies to Solid Tumors

1 Mar 2025

Abstract excerpt

BACKGROUND: The ten-eleven translocation (TET) enzyme family is a key regulator of DNA methylation, responsible for the conversion of 5-methylcytosine to 5-hydroxymethylcytosine to promote locus-specific demethylation. Thus, it is not surprising that loss or attenuation of TET enzymes is implicated in genomic hypermethylation and transcriptional reprogramming that drives cancer development. Somatic mutations in...

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PMID: 40116537
DOI: 10.1002/cam4.70792

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