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Article

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights.

Clinical epigenetics - 9 Nov 2024

Gao Qiang, Shen Kefeng, Xiao Min

Abstract excerpt

TET2 is a critical gene that regulates DNA methylation, encoding a dioxygenase protein that plays a vital role in the regulation of genomic methylation and other epigenetic modifications, as well as in hematopoiesis. Mutations in TET2 are present in 7%-28% of adult acute myeloid leukemia (AML) patients. Despite this, the precise mechanisms by which TET2 mutations contribute to malignant transformation and how...

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Identifiers

PMID: 39521964
DOI: 10.1186/s13148-024-01771-2
PMCID: PMC11550532

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