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Article

[TET2 as a gatekeeper for hematologic malignancies].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jun 2015

Muto Hideharu, Sakata-Yanagimoto Mamiko, Chiba Shigeru

Abstract excerpt

TET (Ten Eleven Translocation) family proteins are dioxygenases that convert methylcytosine to hydroxymethylcytosine, and play an important role in the DNA demethylation process. Most notably, TET2 mutations have frequently been identified in myeloid malignancies, such as myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), chronic myelomonocytic leukemia, and acute myeloid leukemias, as well as...

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Topics

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Share to Dioxygenases
Share to DNA-Binding Proteins
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hematologic Neoplasms

Share to Mutation

Share to Proto-Oncogene Proteins

Share to Translocation, Genetic

Source

Identifiers

PMID: 26256875
DOI: 10.11406/rinketsu.56.651

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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