Article
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
Cancer cell - 12 Jul 2011
Quivoron Cyril, Couronné Lucile, Della Valle Véronique, Lopez Cécile K, Plo Isabelle, Wagner-Ballon Orianne, Do Cruzeiro Marcio, Delhommeau Francois, Arnulf Bertrand, Stern Marc-Henri, Godley Lucy, Opolon Paule, Tilly Hervé, Solary Eric, Duffourd Yannis, Dessen Philippe, Merle-Beral Hélène, Nguyen-Khac Florence, Fontenay Michaëla, Vainchenker William, Bastard Christian, Mercher Thomas, Bernard Olivier A
Abstract excerpt
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2 gene have been described in various human myeloid malignancies. We report that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive advantage, and eventually leads to the development...
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