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Article

TET2: A cornerstone in normal and malignant hematopoiesis.

Cancer science - 1 Jan 2021

Kunimoto Hiroyoshi, Nakajima Hideaki

Abstract excerpt

Regulation of genome-wide DNA methylation is fundamental for a variety of biological processes such as mammalian development, stem cell function, cellular proliferation/differentiation, and oncogenesis. Among the regulators of DNA methylation, ten-eleven translocation 2 (TET2) is one of the most frequently mutated genes in clonal hematopoiesis of indeterminate potential and in various hematological malignancies,...

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Acute Myeloid Leukemia Research
Cell Differentiation
Cell Transformation, Neoplastic
DNA-Binding Proteins
DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33048426
DOI: 10.1111/cas.14688
PMCID: PMC7780023

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