Article
Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.
Molecular cancer - 16 Feb 2016
Yeh Chien-Hung, Bai Xue Tao, Moles Ramona, Ratner Lee, Waldmann Thomas A, Watanabe Toshiki, Toshiki Watanabe, Nicot Christophe
Abstract excerpt
BACKGROUND: Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tumor suppressor genes. While mutations of epigenetic regulators have been reported in various lymphoid malignancies...
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