Article
Variable Intra-Tumor Genomic Heterogeneity of Multiple Lesions in Patients With Hepatocellular Carcinoma.
Gastroenterology - 1 Apr 2016
Xue Ruidong, Li Ruoyan, Guo Hua, Guo Lin, Su Zhe, Ni Xiaohui, Qi Lisha, Zhang Ti, Li Qiang, Zhang Zemin, Xie Xiaoliang Sunney, Bai Fan, Zhang Ning
Abstract excerpt
BACKGROUND & AIMS: Many patients with hepatocellular carcinoma (HCC) have multiple lesions (primary tumors, intrahepatic metastases, multiple occurrences, satellite nodules, and tumor thrombi); these have been associated with a poor prognosis and tumor recurrence after surgery. We investigated the clonal relationship among these lesions on the basis of genetic features. METHODS: We collected 43 lesions and 10...
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