Article
Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma.
Journal of hepatology - 1 Dec 2017
Torrecilla Sara, Sia Daniela, Harrington Andrew N, Zhang Zhongyang, Cabellos Laia, Cornella Helena, Moeini Agrin, Camprecios Genis, Leow Wei-Qiang, Fiel Maria Isabel, Hao Ke, Bassaganyas Laia, Mahajan Milind, Thung Swan N, Villanueva Augusto, Florman Sander, Schwartz Myron E, Llovet Josep M
Abstract excerpt
BACKGROUND & AIMS: According to the clonal model of tumor evolution, trunk alterations arise at early stages and are ubiquitous. Through the characterization of early stages of hepatocarcinogenesis, we aimed to identify trunk alterations in hepatocellular carcinoma (HCC) and study their intra- and inter-tumor distribution in advanced lesions. METHODS: A total of 151 samples representing the multistep process of...
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