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Article

Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.

Journal of hepatology - 1 Aug 2017

Huang Ao, Zhao Xin, Yang Xin-Rong, Li Fu-Qiang, Zhou Xin-Lan, Wu Kui, Zhang Xin, Sun Qi-Man, Cao Ya, Zhu Hong-Mei, Wang Xiang-Dong, Yang Huan-Ming, Wang Jian, Tang Zhao-You, Hou Yong, Fan Jia, Zhou Jian

Abstract excerpt

BACKGROUND & AIMS: Identifying target genetic mutations in hepatocellular carcinoma (HCC) for therapy is made challenging by intratumoral heterogeneity. Circulating cell-free DNAs (cfDNA) may contain a more complete mutational spectrum compared to a single tumor sample. This study aimed to identify the most efficient strategy to identify all the mutations within heterogeneous HCCs. METHODS: Whole exome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28323123
DOI: 10.1016/j.jhep.2017.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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