Current Issues on Genomic Heterogeneity in Hepatocellular Carcinoma and its Implication in Clinical Practice

Abstract excerpt

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease leading to a major diversity. Since staging systems are used in patient care, molecular and histopathological features remain to be incorporated in management algorithms. HCC, as other malignant solid tumors, exhibit a complex genetic diversity and genomic instability, driving tumorigenesis. The recent development of deep sequencing techniques has...

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