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Article

The significance of intertumor and intratumor heterogeneity in liver cancer.

Experimental & molecular medicine - 5 Jan 2018

Liu Jinping, Dang Hien, Wang Xin Wei

Abstract excerpt

Genomic analyses of primary liver cancer samples reveal a complex mutational landscape with vast intertumor and intratumor heterogeneity. Different primary liver tumors and subclones within each tumor display striking molecular and biological variations. Consequently, tumor molecular heterogeneity contributes to drug resistance and tumor relapse following therapy, which poses a substantial obstruction to...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

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Source

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Identifiers

PMID: 29303512
DOI: 10.1038/emm.2017.165
PMCID: PMC5992990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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