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Article

Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing.

Cell research - 1 Mar 2018

Duan Meng, Hao Junfeng, Cui Sijia, Worthley Daniel L, Zhang Shu, Wang Zhichao, Shi Jieyi, Liu Longzi, Wang Xiaoying, Ke Aiwu, Cao Ya, Xi Ruibin, Zhang Xiaoming, Zhou Jian, Fan Jia, Li Chong, Gao Qiang

Abstract excerpt

Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and phenotypic diversity. Yet we do not understand the relationship between intratumor heterogeneity and the associated morphologic/histological characteristics of the tumor. Using single-cell whole-genome sequencing to profile 96 tumor cells (30-36 each) and 15 normal liver cells (5 each), collected from three male patients with...

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Identifiers

PMID: 29327728
DOI: 10.1038/cr.2018.11
PMCID: PMC5835770

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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