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Article

Tumor Heterogeneity in Hepatocellular Carcinoma: Facing the Challenges

1 Jan 2016

Abstract excerpt

Tumor heterogeneity in hepatocellular carcinoma (HCC), such as that found in second primary tumors after curative treatment, synchronous multifocal tumors of different clonality, or intratumor heterogeneity, poses severe challenges for the development and administration of systemic molecular targeted therapies. Various methodologies, including historical DNA ploidy analysis, integrated hepatitis B virus DNA...

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PMID: 27386431
DOI: 10.1159/000367754

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