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Article

Multiregional whole-genome sequencing of hepatocellular carcinoma with nodule-in-nodule appearance reveals stepwise cancer evolution.

The Journal of pathology - 1 Dec 2020

Takeda Haruhiko, Takai Atsushi, Kumagai Ken, Iguchi Eriko, Arasawa Soichi, Eso Yuji, Shimizu Takahiro, Ueda Yoshihide, Taura Kojiro, Uemoto Shinji, Kita Ryuichi, Haga Hironori, Marusawa Hiroyuki, Fujimoto Akihiro, Seno Hiroshi

Abstract excerpt

Recent genetic analyses revealed genetic heterogeneity in hepatocellular carcinoma (HCC), although it remains unclear how genetic alterations contribute to the multistage progression of HCC, especially the early step from hypovascular liver nodules to hypervascular HCC. We conducted multiregional whole-genome sequencing on HCCs with a nodule-in-nodule appearance, consisting of inner hypervascular HCC surrounded...

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Source

Identifiers

PMID: 32815153
DOI: 10.1002/path.5533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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