Article
Mutation spectrum of POLE and POLD1 mutations in South East Asian women presenting with grade 3 endometrioid endometrial carcinomas.
Gynecologic oncology - 1 Apr 2016
Wong Adele, Kuick Chik Hong, Wong Wai Loong, Tham Jill M, Mansor Sorsiah, Loh Eva, Jain Sudhanshi, Vikas Nadkarni N, Tan Sze Huey, Chan Sock Hoai, Li Shao Tzu, Chew Sung Hock, Hong Wanjin, Ngeow Joanne
Abstract excerpt
OBJECTIVE: Somatic POLE mutations have been found in a subset of endometrioid ECs particularly in FIGO grade 3 tumors while POLD1 mutations are reportedly rare in ECs. While it has been suggested that POLE mutation confers good prognosis, the data remains conflicting. Our study aims to determine the mutation spectrum of somatic and germline POLE and POLD1 gene mutations in South East Asian (SEA) women with FIGO...
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