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Article

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2016

McConechy Melissa K, Talhouk Aline, Leung Samuel, Chiu Derek, Yang Winnie, Senz Janine, Reha-Krantz Linda J, Lee Cheng-Han, Huntsman David G, Gilks C Blake, McAlpine Jessica N

Abstract excerpt

PURPOSE: The aim of this study was to confirm the prognostic significance of POLE exonuclease domain mutations (EDM) in endometrial carcinoma patients. In addition, the effect of treatment on POLE-mutated tumors was assessed. EXPERIMENTAL DESIGN: A retrospective patient cohort of 496 endometrial carcinoma patients was identified for targeted sequencing of the POLE exonuclease domain, yielding 406 evaluable...

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Source

Identifiers

PMID: 26763250
DOI: 10.1158/1078-0432.CCR-15-2233

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.PMID 26763250Read ↗

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