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Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.

Gynecologic oncology - 1 Mar 2024

Casanova Joao, Duarte Gonçalo Silva, da Costa Ana Gomes, Catarino Ana, Nave Mónica, Antunes Telma, Serra Sofia Silvério, Dias Sara Simões, Abu-Rustum Nadeem, Lima Jorge

Abstract excerpt

BACKGROUND: POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. OBJECTIVES: To determine the association between POLE mutational status and the...

Topics

Female
Humans
Carcinoma, Endometrioid
DNA Polymerase II
Endometrial Neoplasms
Mutation
Neoplasm Grading
Poly-ADP-Ribose Binding Proteins
Prognosis
Progression-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38262245
DOI: 10.1016/j.ygyno.2024.01.018
PMCID: PMC11290341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.PMID 38262245Read ↗

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