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Article

Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.

Gynecologic oncology - 1 Mar 2024

Casanova Joao, Duarte Gonçalo Silva, da Costa Ana Gomes, Catarino Ana, Nave Mónica, Antunes Telma, Serra Sofia Silvério, Dias Sara Simões, Abu-Rustum Nadeem, Lima Jorge

Abstract excerpt

BACKGROUND: POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. OBJECTIVES: To determine the association between POLE mutational status and the...

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Source

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Identifiers

PMID: 38262245
DOI: 10.1016/j.ygyno.2024.01.018
PMCID: PMC11290341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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