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Frequent POLE-Driven Hypermutation in Ovarian Endometrioid Cancer Revealed by Mutational Signatures in RNA Sequencing

2021-01-18

Abstract excerpt

<h4>Background: </h4> DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE -driven tumors are characterized by high mutational rates. POLE -driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of endometrioid type. POLE -driven cases possess an abundance of TCT>TAT and TCG>TTG somatic mutations characterized by...

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Literature Corpus work
20309c0a-dadd-5bfa-9f04-d3164e10349b
DOI
10.21203/rs.3.rs-145368/v1
Open publication

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Frequent POLE-Driven Hypermutation in Ovarian Endometrioid Cancer Revealed by Mutational Signatures in RNA SequencingDOI 10.21203/rs.3.rs-145368/v1
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