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Article

Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing.

BMC medical genomics - 22 Jun 2021

Davila Jaime I, Chanana Pritha, Sarangi Vivekananda, Fogarty Zachary C, Weroha S John, Guo Ruifeng, Goode Ellen L, Huang Yajue, Wang Chen

Abstract excerpt

BACKGROUND: DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of endometrioid type. POLE-driven cases possess an abundance of TCT > TAT and TCG > TTG somatic mutations characterized by...

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Source

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Identifiers

PMID: 34158040
DOI: 10.1186/s12920-021-01017-7
PMCID: PMC8218518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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