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Article

The clinicopathology and survival characteristics of patients with POLE proofreading mutations in endometrial carcinoma: A systematic review and meta-analysis.

PloS one - 1 Jan 2022

Jumaah Alaa Salah, Al-Haddad Hawraa Sahib, McAllister Katherine Ann, Yasseen Akeel Abed

Abstract excerpt

BACKGROUND: Endometrial carcinoma (EC) is classified into four distinct molecular subgroups. Patients with polymerase epsilon exonuclease domain mutated (POLE-EDM) tumors have the best prognosis of all. This meta-analysis consolidated the clinicopathology variations reported in the POLE-mutant subtype and survival parameters in patients with EC. METHODS: The following internet data bases were searched: PubMed,...

Topics

Adult
Aged
Carcinoma, Endometrioid
DNA Polymerase II
Endometrial Neoplasms
Female
Humans
Middle Aged
Mutation
Poly-ADP-Ribose Binding Proteins
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 35139130
DOI: 10.1371/journal.pone.0263585
PMCID: PMC8827442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The clinicopathology and survival characteristics of patients with POLE proofreading mutations in endometrial carcinoma: A systematic review and meta-analysis.PMID 35139130Read ↗

Clinicopathological characteristics and prognostic value of POLE mutations in endometrial cancer: A systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic significance of POLE proofreading mutations in endometrial cancer.Semantic proximity Read ↗

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.Semantic proximity Read ↗

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.Semantic proximity Read ↗

Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.Semantic proximity Read ↗

An exploratory analysis of driver gene alterations and their potential prognostic relevance in endometrial cancer with POLE exonuclease domain mutations.Semantic proximity Read ↗

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The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients.Semantic proximity Read ↗

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Clinicopathological features of pathogenic, non-pathogenic, and unknown significance (NP/US) POLE mutations in endometrial carcinomas: A study based on actual worldSemantic proximity Read ↗

Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.Semantic proximity Read ↗

The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive ReviewSemantic proximity Read ↗

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