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Article

Interpretation of somatic POLE mutations in endometrial carcinoma.

The Journal of pathology - 1 Mar 2020

León-Castillo Alicia, Britton Heidi, McConechy Melissa K, McAlpine Jessica N, Nout Remi, Kommoss Stefan, Brucker Sara Y, Carlson Joseph W, Epstein Elisabeth, Rau Tilman T, Bosse Tjalling, Church David N, Gilks C Blake

Abstract excerpt

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours ('POLE-ultramutated') within the novel molecular classification of endometrial carcinoma (EC). However, clinical implementation of this classifier requires systematic evaluation of the pathogenicity of POLE mutations. To address this, we examined base changes,...

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Source

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Identifiers

PMID: 31829442
DOI: 10.1002/path.5372
PMCID: PMC7065171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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