Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.

doi:10.1097/IGC.0000000000000681

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Article

Prognostic Significance of POLE Exonuclease Domain Mutations in High-Grade Endometrioid Endometrial Cancer on Survival and Recurrence: A Subanalysis.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jun 2016

Billingsley Caroline C, Cohn David E, Mutch David G, Hade Erinn M, Goodfellow Paul J

Abstract excerpt

OBJECTIVE: POLE mutations in high-grade endometrioid endometrial cancer (EEC) have been associated with improved survival. We sought to investigate the prevalence of POLE tumor mutation and its prognostic significance on outcomes and clinical applications in a subanalysis of women with high-grade EEC from a previously described cohort of 544 EEC patients in which POLE mutation status and survival outcomes were...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Endometrioid
Case-Control Studies
DNA Polymerase II
Endometrial Neoplasms
Female
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Grading

Neoplasm Recurrence, Local

Poly-ADP-Ribose Binding Proteins

Prognosis

Protein Domains

Survival Rate

Source

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Identifiers

PMID: 26937754
DOI: 10.1097/IGC.0000000000000681
PMCID: PMC4874836

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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