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Article

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.

Journal of gynecologic oncology - 1 May 2022

Yu Shuangni, Sun Zezheng, Zong Liju, Yan Jie, Yu Mei, Chen Jie, Lu Zhaohui

Abstract excerpt

OBJECTIVE: The molecular classification system of endometrial carcinoma (EC) in 'The Cancer Genome Atlas' is widely acknowledged for its prognostic utility. Subsequently, more simplified classification system that incorporate DNA polymerase epsilon (POLE) exonuclease domain mutations, mismatch repair deficiencies (MMRd), and abnormal p53 (P53abn) has also demonstrated its clinical utility. These classifications...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35320887
DOI: 10.3802/jgo.2022.33.e38
PMCID: PMC9024187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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