Article
Endometrial cancer with a POLE mutation progresses frequently through the type I pathway despite its high-grade endometrioid morphology: a cohort study at a single institution in Japan.
Medical molecular morphology - 1 Jun 2021
Monsur Mahina, Yamaguchi Munekage, Tashiro Hironori, Yoshinobu Kumiko, Saito Fumitaka, Erdenebaatar Chimeddulam, Li Chenyan, Iwagoi Yutaka, Ohba Takashi, Iyama Ken-Ichi, Katabuchi Hidetaka
Abstract excerpt
POLE-mutated endometrial cancer (EC) frequently shows high-grade endometrioid histology, which represents heterogeneity in the dualistic classification of EC. This study aimed to assess the clinicopathology and pathogenesis of POLE-mutated EC due to the scarcity of related information for Asian women. POLE variants were sequenced in tissues of Japanese women with EC. The tumor mutation burden (TMB) was assessed...
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