Article
Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer.
Clinical lung cancer - 1 Jul 2016
Li Peng, Wang Xiaohong, Liu Zhensheng, Liu Hongliang, Xu Ting, Wang HuiJuan, Gomez Daniel R, Nguyen Quynh-Nhu, Wang Li-E, Teng Yuee, Song Yipeng, Komaki Ritsuko, Welsh James W, Wei Qingyi, Liao Zhongxing
Abstract excerpt
BACKGROUND: The immune system has important roles in tumor development and outcomes after cancer treatment. We evaluated whether single-nucleotide polymorphisms (SNPs) in the gene encoding casitas B-lineage lymphoma b protein (Cbl-b), an E3 ubiquitin ligase that maintains immune tolerance by negatively regulating T-cell activation and function, were associated with outcomes after treatment of non-small-cell lung...
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