Article
Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer.
International journal of radiation oncology, biology, physics - 1 Apr 2013
Pang Qingsong, Wei Qingyi, Xu Ting, Yuan Xianglin, Lopez Guerra Jose Luis, Levy Lawrence B, Liu Zhensheng, Gomez Daniel R, Zhuang Yan, Wang Li-E, Mohan Radhe, Komaki Ritsuko, Liao Zhongxing
Abstract excerpt
PURPOSE: To date, no biomarkers have been found to predict, before treatment, which patients will develop radiation pneumonitis (RP), a potentially fatal toxicity, after chemoradiation for lung cancer. We investigated potential associations between single nucleotide polymorphisms (SNPs) in HSPB1 and risk of RP after chemoradiation for non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Subjects were...
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