Article
Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy.
Cancer - 15 Jan 2012
Yin Ming, Liao Zhongxing, Liu Zhensheng, Wang Li-E, O'Reilly Michael, Gomez Daniel, Li Minghuan, Komaki Ritsuko, Wei Qingyi
Abstract excerpt
BACKGROUND: Nonhomologous end joining (NHEJ) is a pathway that repairs DNA double-strand breaks (DSBs) to maintain genomic stability in response to irradiation. The authors hypothesized that single nucleotide polymorphisms (SNPs) in NHEJ repair genes may affect clinical outcomes in patients with nonsmall cell lung cancer (NSCLC) who receive definitive radio(chemo)therapy. METHODS: The authors genotyped 5...
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